This book constitutes the proceedings of the 17th International Conference on Discovery Science, DS 2016, held in banff, AB, Canada in October 2015. The 30 full papers presented together with 5 abstracts of invited talks in this volume were carefully reviewed and selected from 60 submissions. The conference focuses on following topics: Advances in the development and analysis of methods for discovering scientiï¬c knowledge, coming from machine learning, data mining, and intelligent data analysis, as well as their application in various scientiï¬c domains.