First published in 1986: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics metabolic activation and key defense mechanisms excretion species variation and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction and specificity in tumor initiation are also examined. Of primary interest to toxicologist pharma-cologists biochemists and environmental toxicologists. |Target Organ Toxicity Volume 2 | Life Science