"Drug-Drug Interactions | Chemistry

Authored by renowned leaders in the field this comprehensive volume covers all aspects of drug-drug interactions including preclinical clinical toxicological and regulatory perspectives. Thoroughly updated this second edition reflects the significant advances and includes extensive new material on: key interplay between transporters and enzymes in drug metabolism and drug interactions the integral role of pharmacogenetics in metabolism-based drug-drug interactions in vivo – in vitro correlations (reversible mechanism-based inhibition induction) in silico approaches enabling structure-activity and structure-function studies high-throughput screening and GLP methods for evaluating drug interactions in vitro the use of transgenic animal models to evaluate drug interactions Providing helpful case examples and computer-aided modeling Drug-Drug Interactions is filled with over 200 invaluable tables equations and figures to clarify key concepts and incorporates critical new updated information.|Drug-Drug Interactions | Chemistry