Pathology Of The Developing Mouse A Systematic Approach | Life Science

Pathology of the Developing Mouse provides in so far as feasible one complete reference on the design analysis and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular this book is designed specifically to be not only a how to do manual for developmental pathology experimentation in mice but more importantly a how to interpret resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity. The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: baseline anatomic and physiologic traits of developing miceprinciples of good experimental design and statistical analysis for mouse developmental pathology studiesprocedures for anatomic pathology examinations to evaluate structural changes at the macroscopic (gross) microscopic (cells and tissues) and ultrastructural (subcellular) levels suing conventional autopsy-based or novel non-invasive imaging techniques;methods for clinical pathology testing to assess the biochemical and cellular composition of tissues and fluids; options and protocols for in situ molecular pathology analysis to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e. lesions) during development; and well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos fetuses neonates and juveniles) and its support system (placenta). |Pathology of the Developing Mouse A Systematic Approach | Life Science