Contents: L. Banfi â A. Basso â R. Riva: Synthesis of Heterocycles Through Classical Ugi and Passerini Reactions Followed by Secondary Transformations Involving One or Two Additional Functional Groups.- V.A. Chebanov â K. A. Gura â S.M. Desenko: Aminoazoles as Key Reagents in Multicomponent Heterocyclizations.- Y. Huang â K. Khoury â A. Dömling: Piperazine Scaffolds by Multicomponent 3 Reactions: The Piperazine Space 4 in MCR Chemistry 5 Deep MCR Piperazine Space.- N. Elders â E. Ruijter â V.G. Nenajdenko â R.V.A. Orru: α-Acidic Isocyanides in Multicomponent Chemistry.- A. Cukalovic â J.-C.M.R. Monbaliu â C.V. Stevens: Microreactor Technology as an Efficient Tool for Multicomponent Reactions.- L.A. Wessjohann â C.R.B. Rhoden â D.G. Rivera â O. Eichler Vercillo: Cyclic Peptidomimetics and Pseudopeptides from Multicomponent Reactions.- M. del Mar Sanchez Duque â C. Allais â N. Isambert â T. Constantieux â J. Rodriguez: Ã-Diketo Building Blocks for MCRs-Based Syntheses of Heterocycles