Cytochrome P450 2D6 Structure Function Regulation And Polymorphism | Life Scienc

Cytochromes are proteins that catalyze electron transfer reactions of well-known metabolic pathways and are classified in various superfamilies. The CYP or P450 superfamily accounts for 90% of the oxidative metabolism of clinical drugs. One member of this superfamily P450 2D6 (or CYP2D6) singlehandedly metabolizes about 25% of all medications in the human liver. Cytochrome P450 2D6: Structure Function Regulation and Polymorphism reviews the current knowledge of CYP2D6 as well as the maturing body of evidence indicating its significance to clinical and pharmacological researchers and practitioners. This book focuses on the critical role CYP2D6 plays in the human liver. It examines the genetic epigenetic physiological pathological and structural factors of the gene that govern the highly variable metabolism of a number of drugs in clinical use. It highlights the impact of the functional roles of CYP2D6 on clinical practice and drug development and also discusses implications for precise medicine strategies to avoid adverse drug reactions and paths for future research. Cytochrome P450 2D6 is a unique valuable book focusing on a single but immensely powerful human gene. It provides the first single source of comprehensive information on CYP2D6 that serves as an important reference for medical biomedical pharmaceutical and nursing researchers practitioners and students. |Cytochrome P450 2D6 Structure Function Regulation and Polymorphism | Life Science